DEPARTMENT OF UROLOGY - RESEARCH

Early Detection/Biomarker Studies

    Biomarker Discovery for Renal Cell Carcinoma Through Serum, Urine and Tissue Protein Profiles

    Objective

    To enroll 200 patients undergoing Partial or Radical Nephrectomy for Renal Cell Carcinoma To characterize changes in blood and urine after tumor resection and to compare these changes with protein profiles of resected tumor To identify unique patterns in urine or blood that are characteristic of renal cell carcinoma To identify specific markers for renal cell carcinoma To establish a biorepository of renal tumors with pre and post blood and urine samples for future studies of biomarkers for renal cell carcinoma and genetic risk factors for the disease

    Eligibility

    Patients with a solid renal mass scheduled to undergo either partial or radical nephrectomy for renal cell carcinoma Able to provide serum and urine samples at pre-operative visit, and at Months 1, 2 and 3 postoperatively Able to undergo surgery such that tissue samples are available for analysis No diagnosis of other cancers unless currently without evidence of disease Prior treatment for renal cell carcinoma

    Randomization

    None

    Treatment

    Partial or Radical Nephrectomy

    Follow-Up

    Baseline visit-pre-surgery blood and urine collection Surgery Months 1,2,3 post-operative visits for blood and urine collection

    Sponsor

    The Department of Urology, UT Health Science Center San Antonio

  • San Antonio Center of Biomarkers of Risk for Prostate Cancer (SABOR)

    Sponsor

    National Institutes of Health

  • Identification of Protein and Genetic Biomarkers of Prostate Cancer and Risk Factors for Progression of Disease (PREF)

    Sponsor

    National Institutes of Health

  • back to top ^